2291 Reaction dynamics of the chimeric channelrhodopsin C1C2 Y. Hontani, M. Marazzi, K. Stehfest, T. Mathes, I. H. M. van Stokkum, M. Elstner, P. Hegemann, J. T. M. Kennis Scientific Reports 2017, 7, 10.1038/s41598-017-07363-w
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2290 Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson J. Vierock, C. Grimm, N. Nitzan, P. Hegemann Scientific Reports 2017, 7, 10.1038/s41598-017-09600-8
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2289 The form and function of channelrhodopsin K. Deisseroth, P. Hegemann Science 2017, 357, 10.1126/science.aan5544
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2288 The two parallel photocycles of theChlamydomonassensory photoreceptor histidine kinase rhodopsin 1 M. Luck, P. Hegemann Journal of Plant Physiology 2017, 217, 77–84, 10.1016/j.jplph.2017.07.008
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2287 Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function J. C. D. Kaufmann, B. S. Krause, C. Grimm, E. Ritter, P. Hegemann, F. J. Bartl Journal of Biological Chemistry 2017, 292, 14205–14216, 10.1074/jbc.M117.779629
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2286 Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR B. S. Krause, C. Grimm, J. C. D. Kaufmann, F. Schneider, T. P. Sakmar, F. J. Bartl, P. Hegemann Biophysical Journal 2017, 112, 1166–1175, 10.1016/j.bpj.2017.02.001
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2038 Optogenetic acidification of synaptic vesicles and lysosomes B. R. Rost, F. Schneider, M. K. Grauel, C. Wozny, C. G Bentz, A. Blessing, T. Rosenmund, T. J. Jentsch, D. Schmitz, P. Hegemann, C. Rosenmund Nature Neuroscience 2015, 18, 1845–1852, 10.1038/nn.4161
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2037 Optogenetic approaches addressing extracellular modulation of neural excitability E. A. Ferenczi, J. Vierock, K. Atsuta-Tsunoda, S. P. Tsunoda, C. Ramakrishnan, C. Gorini, K. Thompson, S. Y. Lee, A. Berndt, C. Perry, S. Minniberger, A. Vogt, J. Mattis, R. Prakash, S. Delp, K. Deisseroth, P. Hegemann Scientific Reports 2016, 6, 23947– 10.1038/srep23947
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2036 Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity A. Berndt, S. Y. Lee, J. Wietek, C. Ramakrishnan, E. E. Steinberg, A. J. Rashid, H. Kim, S. Park, A. Santoro, P. W. Frankland, S. M. Iyer, S. Pak, S. Ährlund-Richter, S. L. Delp, R. C. Malenka, S. A. Josselyn, M. Carlén, P. Hegemann, K. Deisseroth Proceedings of the National Academy of Sciences 2016, 113, 822–829, 10.1073/pnas.1523341113
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2035 Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy P. E. Konold, T. Mathes, J. Weiβenborn, M. L. Groot, P. Hegemann, J. T. M. Kennis The Journal of Physical Chemistry Letters 2016, 7, 3472–3476, 10.1021/acs.jpclett.6b01484
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2034 Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain ofChlamydomonas reinhardtiiPhototropin J. Zhu, T. Mathes, Y. Hontani, M. T. A. Alexandre, K. C. Toh, P. Hegemann, J. T. M. Kennis The Journal of Physical Chemistry Letters 2016, 7, 4380–4384, 10.1021/acs.jpclett.6b02075
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1669 Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1 M. Luck, S. Bruun, A. Keidel, P. Hegemann, P. Hildebrandt FEBS Letters 2015, 589, 1067–1071, 10.1016/j.febslet.2015.03.024
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1467 Controlling fertilization and cAMP signaling in sperm by optogenetics V. Jansen, L. Alvarez, M. Balbach, T. Strünker, P. Hegemann, U. B. Kaupp, D. Wachten eLife 2015, 4, 10.7554/eLife.05161
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1402 Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase C. Gasser, S. Taiber, C. M. Yeh, C. H. Wittig, P. Hegemann, S. Ryu, F. Wunder, A. Möglich Proceedings of the National Academy of Sciences 2014, 10.1073/pnas.1321600111
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1358 A Photochromic Histidine Kinase Rhodopsin (HKR1) That Is Bimodally Switched by Ultraviolet and Blue Light M. Luck, T. Mathes, S. Bruun, R. Fudim, R. Hagedorn, T. M. Tran Nguyen, S. Kateriya, J. T. M. Kennis, P. Hildebrandt, P. Hegemann Journal of Biological Chemistry 2012, 287, 40083–40090, 10.1074/jbc.M112.401604
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1258 Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms O. P. Ernst, D. T. Lodowski, M. Elstner, P. Hegemann, L. S. Brown, H. Kandori Chemical Reviews 2014, 114, 126–163, 10.1021/cr4003769
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1122 P. Hegemann, S. Sigrist Optogenetics De Gruyter 2013,
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1120 Towards an Understanding of Channelrhodopsin Function: Simulations Lead to Novel Insights of the Channel Mechanism H. C. Watanabe, K. Welke, D. J. Sindhikara, P. Hegemann, M. Elstner Journal of Molecular Biology 2013, 425, 1795–1814, 10.1016/j.jmb.2013.01.033
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1118 From channelrhodopsins to optogenetics P. Hegemann, G. Nagel EMBO Molecular Medicine 2013, 5, 173–176, 10.1002/emmm.201202387
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1117 Optogenetic Modulation of an Adenylate Cyclase in Toxoplasma gondii Demonstrates a Requirement of the Parasite cAMP for Host-Cell Invasion and Stage Differentiation A. Hartmann, R. D. Arroyo-Olarte, K. Imkeller, P. Hegemann, R. Lucius, N. Gupta Journal of Biological Chemistry 2013, 288, 13705–13717, 10.1074/jbc.M113.465583
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773 The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant S. Bruun, H. Naumann, U. Kuhlmann, C. Schulz, K. Stehfest, P. Hegemann, P. Hildebrandt FEBS letters 2011, 585, 3998–4001, 10.1016/j.febslet.2011.11.007
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643 Neocortical excitation/inhibition balance in information processing and social dysfunction O. Yizhar, L. E. Fenno, M. Prigge, F. Schneider, T. J. Davidaon, D. J. O\'Shea, V. S. Sohal, I. Goshen, J. Finkelstein, J. T. Paz, K. Stehfest, R. Fudim, C. Ramakrishnan, J. R. Huguenard, P. Hegemann, K. Deisseroth Nature 2011, 477, 171–148, 10.1038/nature10360
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624 Hindered Rotation of a Cofactor Methyl Group as a Probe for Protein−Cofactor Interaction R. Brosi, B. Illarionov, T. Mathes, M. Fischer, M. Joshi, A. Bacher, P. Hegemann, R. Bittl, S. Weber, E. Schleicher Journal of the American Chemical Society 2010, 132, 8935–8944, 10.1021/ja910681z
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324 Ultrafast optogenetics: precise neural control beyond the gamma band L. A. Gunaydin, O. Yizhar, A. Berndt, V. S. Sohal, K. Deisseroth, P. Hegemann Nature Neuroscience 2010, 13, 387–393, 10.1038/nn.2495
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323 Absorption and emission spectroscopic characterization of BLUF protein Slr1694 from Synechocystis sp. PCC6803 with roseoflavin cofactor P. Zirak, A. Penzkofer, T. Mathes, P. Hegemann Journal of Photochemistry and Photobiology B: Biology 2009, 97, 61–70, 10.1016/j.jphotobiol.2009.08.002
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322 Bi-stable neural state switches A. Berndt, O. Yizhar, L. A. Gunaydin, P. Hegemann, K. Deisseroth Nature Neuroscience 2009, 12, 229–234, 10.1038/nn.2247
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266 Absorption and emission spectroscopic characterization of 8-amino-riboflavin A. Tyagi, P. Zirak, A. Penzkofer, T. Mathes, P. Hegemann, M. Mack, S. Ghisla Chemical Physics 2009, 364, 19–30, 10.1016/j.chemphys.2009.08.005
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180 Glu87 of Channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation. S. Tsunoda, P. Hegemann Photochemistry & Photobiology 2009, 85, 564–569, 10.1111/j.1751-1097.2008.00519.x
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178 Redshifted optogenetic excitation: A novel tool for fast neural control derived from Volvox carteri. K. Deisseroth, P. Hegemann, O. Yizhar, J. Mattis, S. Tsunoda, F. Beyrière, M. Prigge, F. Zhang Nature Neuroscience 2008, 11, 631–633, 10.1038/nn.2120
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