Prof. Dr. Holger Dobbek
Member of UniCat's Executive Board since November 2010
Research interests
Enzymology of reductive CO/CO2 metabolism in bacteria, oxidation state dependent host-guest recognition in biology, molybdoenzymes, iron-sulfur cluster, flavoenzymes, X-ray crystallography
Research Fields in UniCat
Research Field D2
Research Field E2*
Research Field E3
Research Field E4
* Main Research Field
2009-2011: B2
Selection of research projects
- Stabilization and characterization of various adducts bound to enzymes containing O2-sensitive iron-sulfur cluster
- Analysing the function of flavoenzymes by combining single-turnover kinetics and X-ray crystallography
- Structural analysis of an O2-sensitive Mo-Se containing enzyme
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Relevant News
A super adhesive made from intestinal bacteria
Manufacturing mussel-based underwater adhesives for healing bone fractures with the help of reprogramed intestinal bacteria / spin-off planned
Photosystem II without Mn4CaO5-Cluster
New research highlight: Holger Dau, Holger Dobbek, Athina Zouni, and coworkers reveal structural insights into the light-driven auto-assembly process of the water-oxidizing Mn4CaO5-cluster in photosystem II.
Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
New research highlight: Peter Hildebrandt, Holger Dobbek, Ingo Zebger, and coworkers investigate the Michaelis complex of the flavoenzyme xenobiotic reductase A with the reactive reduced cofactor bound to its substrates by X-ray crystallography and resonan
Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide
The biocatalytic function of carbon monoxide dehydrogenase (CODH) has a high environmental relevance owing to its ability to reduce CO2. Despite numerous studies on CODH over the past decades, its catalytic mechanism is not yet fully understood. In the pre
Reserach Highlight "Structure of photosystem II and substrate binding at room temperature"
Here we report the use of femtosecond pulses from an X-ray free electron laser (XFEL) to obtain damage-free, room temperature structures of dark-adapted (S1), two-flash illuminated (2F; S3-enriched), and ammonia-bound two-flash illuminated (2F-NH3; S3-enri
A blue-print for the activation of Carbon Dioxide
The activation and conversion of carbon dioxide into added-value products is of economical and ecological importance. [more]
How to energize an electron
When an organic chemist needs strong reducing power he can turn to elemental alkali metals in an aprotic medium. When a physiological process requires an “energized” electron, it has to realize it without elemental metals as electron source and within an a[more]
Iron-Sulfur Enzymes - Mechanisms and Applications in Energy, Environment and Medicine
UniCat scientists Silke Leimkühler, Holger Dobbek, and Oliver Lenz have been invited to the Gordon Research Conference on Iron-Sulfur Enzymes[more]
News and impressions from General Assembly meeting
Yesterday, Prof. Matthias Driess opened the meeting of the General Assembly and welcomed guests and members of UniCat. Two new members of UniCat presented their research work. Prof. Arne Thomas (TU Berlin) gave a talk on "Functional Porous Material[more]